Keeping your hands clean is one of the best ways to prevent infections and illness from being spread around. Wet your hands with clean warm water. Apply soap and rub your hands together lathering up the soap. Make sure you get all the parts of your hands including the backs, under your nails, and between your fingers. Continue to scrub for at least 25 seconds. Then you can rinse your hands under running water and dry with a clean towel.